MK-2048

MK-2048 is a drug that was investigated for the prevention of HIV infection. The drug failed to show a difference in treatment and control arms in Phase I trials. No further studies are planned.

In the Vinony graph

Within Vinony's link graph, MK-2048 is referenced by 126 other articles, and connects out to tenofovir alafenamide, nucleoside analogue and medication.

It is catalogued under topics including Chemical pages without DrugBank identifier, Drugs not assigned an ATC code and ECHA InfoCard ID from Wikidata.

Its subject is documented across 6 Wikipedia language editions.

Chemical data

Formula: C21H21ClFN5O4
Molecular weight: 461.9 g/mol
IUPAC name: (13S)-5-[(3-chloro-4-fluorophenyl)methyl]-11-ethyl-8-hydroxy-N,13-dimethyl-6,10-dioxo-1,4,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),3,8-triene-3-carboxamide
SMILES: CCN1C[C@@H](N2C3=C(C(=C2C1=O)O)C(=O)N(N=C3C(=O)NC)CC4=CC(=C(C=C4)F)Cl)C
InChIKey: JSRREMIKIHJGAA-JTQLQIEISA-N
XLogP: 2.3
Polar surface area: 107 Å²
H-bond donors: 2
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Molecule type: Small molecule

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 461.12661005200005

Show 4 more facts

chemical formula: C₂₁H₂₁ClFN₅O₄
canonical SMILES: CCN1CC(N2C3=C(C(=C2C1=O)O)C(=O)N(N=C3C(=O)NC)CC4=CC(=C(C=C4)F)Cl)C
isomeric SMILES: CCN1C[C@@H](N2C3=C(C(=C2C1=O)O)C(=O)N(N=C3C(=O)NC)CC4=CC(=C(C=C4)F)Cl)C
Commons category: MK-2048

Sources (2)

via Wikidata · CC0

~2 min read

Encyclopedic overview

3 sections

Contents

Design and pre-clinical trials
Clinical trials
References

MK-2048 is a drug that was investigated for the prevention of HIV infection. The drug failed to show a difference in treatment and control arms in Phase I trials. No further studies are planned.

== Design and pre-clinical trials ==

Excerpted from Wikipedia’s “MK-2048” article, available under the CC BY-SA 4.0 licence.