monastrol
Sign in to saveMonastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin-5 (also known as KIF11, Kinesin Eg5), a motor protein important for spindle bipolarity.
Wikidata facts
- Mass
- 292.088163
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- Commons category
- Monastrol
- canonical SMILES
- CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
- chemical formula
- C₁₄H₁₆N₂O₃S
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2 sectionsContents
- Mechanism of action
- References
Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin-5 (also known as KIF11, Kinesin Eg5), a motor protein important for spindle bipolarity.
==Mechanism of action== thumb|Monastrol inhibits Eg5 Monastrol binds to a long loop that is specific to the Eg5 (also known as KIF11 or kinesin-5) kinesin family, and allosterically inhibits ATPase activity of the kinesin
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