Structure via PubChem · Public domain (PubChem)
امپیتیپی
Sign in to saveAlso known as 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound. It is classified as a tetrahydropyridine. It is of interest as a precursor to the monoaminergic neurotoxin MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain. It has been used to study disease models in various animals.
Chemical data
- Formula
- C12H15N
- Molecular weight
- 173.25 g/mol
- IUPAC name
- 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine
- SMILES
- CN1CCC(=CC1)C2=CC=CC=C2
- InChIKey
- PLRACCBDVIHHLZ-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 3.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
11,488 papers- MPTP induces neurodegeneration by modulating dopaminergic activity in catfish brain.Neurotoxicology and teratology · 2023
- Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP.Trends in pharmacological sciences · 2017
- The MPTP model: versatile contributions to the treatment of idiopathic Parkinson's disease.Journal of the neurological sciences · 1990
- The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the cognitive and motor functions in rodents: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2022
- Neurochemical findings in the MPTP model of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2001
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- hydrogen
- Mass
- 173.120449
Show 5 more facts
- chemical formula
- C₁₂H₁₅N
- canonical SMILES
- CN1CCC(=CC1)C2=CC=CC=C2
- melting point
- 39
- subject has role
- dopaminergic
- Commons category
- MPTP
via Wikidata · CC0