MTHFD2

Also known as NMDMC, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial is an enzyme that in humans is encoded by the MTHFD2 gene.

In the Vinony graph

Within Vinony's link graph, MTHFD2 is referenced by 4 other articles, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 2.

Its subject is documented across 5 Wikipedia language editions.

Gene data

MTHFD2

Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Type: protein-coding
Position: 74,186,172–74,218,432 (+)
Aliases: NMDMC
Ensembl: ENSG00000065911
RefSeq RNA: NM_001410192.1, NM_006636.4, XM_006711924.3, XM_054340222.1
RefSeq protein: NP_001397121.1, NP_006627.2, XP_006711987.1, XP_054196197.1

This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009].

Pathways

One carbon pool by folate - Homo sapiens (human)Metabolism Metabolism of folate and pterines Metabolism of water-soluble vitamins and cofactors Metabolism of vitamins and cofactors Folate Metabolism One-carbon metabolism Trans-sulfuration and one-carbon metabolism Nucleotide metabolism

via MyGene.info

Gene · Ensembl

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Symbol: MTHFD2
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:74,186,172-74,218,432
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 21321
genomic start: 74186172
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10797
genomic end: 74444692
chromosome: human chromosome 2
cytogenetic location: 2p13.1
expressed in: tibia

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References
Further reading

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial is an enzyme that in humans is encoded by the MTHFD2 gene.

This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in multiple transcripts encoding different isoforms. This gene has a pseudogene on chromosome 7.

Excerpted from Wikipedia’s “MTHFD2” article, available under the CC BY-SA 4.0 licence.