NDC80

Also known as HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80, NDC80, kinetochore complex component, NDC80 kinetochore complex component

Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.

Gene data

NDC80

Name: NDC80 kinetochore complex component
Type: protein-coding
Position: 2,571,520–2,616,635 (+)
Aliases: HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80
Ensembl: ENSG00000080986
RefSeq RNA: NM_006101.3
RefSeq protein: NP_006092.1

This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011].

Gene Ontology

Biological process

mitotic sister chromatid segregation establishment of mitotic spindle orientation

Article

4 sections

Contents

Function
Interactions
References
Further reading

Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.

== Function == Ndc80 is one of the proteins of outer kinetochore. It forms a heterotetramer with proteins NUF2, SPC25, and SPC24. This protein complex has microtubule-binding domains.