NDC80
Sign in to saveAlso known as HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80, NDC80, kinetochore complex component, NDC80 kinetochore complex component
Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.
Gene data
NDC80- Name
- NDC80 kinetochore complex component
- Type
- protein-coding
- Position
- 2,571,520–2,616,635 (+)
- Aliases
- HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80
- Ensembl
- ENSG00000080986
- RefSeq RNA
- NM_006101.3
- RefSeq protein
- NP_006092.1
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
NDC80 kinetochore complex component
- Symbol
- NDC80
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:2,571,520-2,616,635
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein NDC80 PDB 2igp.png
Show 5 more facts
- HomoloGene ID
- 38141
- exact match
- identifiers.org/ncbigene/10403
- genomic end
- 2616634
- genomic start
- 2571557
- cytogenetic location
- 18p11.32
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.
== Function == Ndc80 is one of the proteins of outer kinetochore. It forms a heterotetramer with proteins NUF2, SPC25, and SPC24. This protein complex has microtubule-binding domains.