Structure via PubChem · Public domain (PubChem)
nedocromil
Sign in to saveAlso known as FPL-59002, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid
Nedocromil sodium is a medication considered a mast cell stabilizer which acts to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade, and as an eye drop under the brand name Alocril. The effects of nedocromil versus asthma are gradual rather than fast-acting and it is not indicated for acute respiratory distress compared to fast acting bronchodilators like albuterol or other well-known inhaler medications. Liquid preparations of nedocromil are available in the UK under the name Rapitil for use for a
Chemical data
- Formula
- C19H17NO7
- Molecular weight
- 371.3 g/mol
- IUPAC name
- 9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid
- SMILES
- CCCC1=C2C(=CC3=C1OC(=CC3=O)C(=O)O)C(=O)C=C(N2CC)C(=O)O
- InChIKey
- RQTOOFIXOKYGAN-UHFFFAOYSA-N
- XLogP
- 2.2
- Polar surface area
- 121 Ų
- H-bond donors
- 2
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Research
873 papers- Nedocromil sodium.The Annals of pharmacotherapy · 1993
- Nedocromil sodium for preventing exercise-induced bronchoconstriction.The Cochrane database of systematic reviews · 2002
- Nedocromil sodium for chronic asthma in children.The Cochrane database of systematic reviews · 2006
- Nedocromil sodium in the treatment of exercise-induced asthma: a meta-analysis.The European respiratory journal · 2000
- Effect of nedocromil sodium on airway sensory nerves.The Journal of allergy and clinical immunology · 1993
via PubMed
Wikidata facts
- Mass
- 371.100502
Show 5 more facts
- chemical formula
- C₁₉H₁₇NO₇
- defined daily dose
- 8
- Commons category
- Nedocromil
- canonical SMILES
- CCCC1=C2C(=CC3=C1OC(=CC3=O)C(=O)O)C(=O)C=C(N2CC)C(=O)O
- World Health Organisation international non-proprietary name
- nedocromil
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- See also
- References
Nedocromil sodium is a medication considered a mast cell stabilizer which acts to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade, and as an eye drop under the brand name Alocril. The effects of nedocromil versus asthma are gradual rather than fast-acting and it is not indicated for acute respiratory distress compared to fast acting bronchodilators like albuterol or other well-known inhaler medications. Liquid preparations of nedocromil are available in the UK under the name Rapitil for use for allergic eye reactions. Nedocromil sodium has been shown to be effective in alleviating symptoms of allergic conjunctivitis.
Nedocromil is classified as a benzopyrone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008 because it used CFCs as propellant.