nicergoline
Sign in to saveAlso known as (8beta)-10-methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyridinecarboxylate (ester), 10-methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate
Nicergoline, sold under the brand name Sermion among others, is an ergot derivative used to treat senile dementia and other disorders with vascular origins. Internationally it has been used for frontotemporal dementia as well as early onset in Lewy body dementia and Parkinson's dementia. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs. Unlike many other ergolines, such as ergotamine, nicergoline is not associate
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 462260029
- Drug.IUPAC_name
- [(6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinolin-9-yl]methyl 5-bromopyridine-3-carboxylate
- Drug.image
- Nicergoline Structure V.1.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200px
- Drug.tradename
- Sermion
- Drug.pregnancy_category
- Not recommended
- Drug.routes_of_administration
- By mouth, intramuscular, intravenous
- Drug.ATC_prefix
- C04
- Drug.ATC_suffix
- AE02
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- <5%
- Drug.protein_bound
- >90%
- Drug.metabolism
- Extensive First-pass metabolism
- Drug.elimination_half life
- 13–20 hours
- Drug.CAS_number
- 27848-84-6
- Drug.PubChem
- 34040
via Wikipedia infobox
Research
478 papers- Therapeutic use of nicergoline.Clinical drug investigation · 2008
- Ergotamine and nicergoline - facts and myths.Pharmacological reports : PR · 2015
- Safety of nicergoline as an agent for management of cognitive function disorders.BioMed research international · 2014
- Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues.Apoptosis : an international journal on programmed cell death · 2023
- Neurotrophic keratopathy: current challenges and future prospects.Annals of medicine · 2022
via PubMed
Wikidata facts
- Mass
- 483.115754
Show 3 more facts
- chemical formula
- C₂₄H₂₆BrN₃O₃
- canonical SMILES
- CN1CC(CC2(C1CC3=CN(C4=CC=CC2=C34)C)OC)COC(=O)C5=CC(=CN=C5)Br
- isomeric SMILES
- CN1C[C@@H](C[C@]2([C@H]1CC3=CN(C4=CC=CC2=C34)C)OC)COC(=O)C5=CC(=CN=C5)Br
Sources (2)
via Wikidata · CC0
~5 min read
Article
10 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Interactions
- Pharmacology
- Pharmacodynamics
- Society and culture
- Generic names
- Brand names
- References
Nicergoline, sold under the brand name Sermion among others, is an ergot derivative used to treat senile dementia and other disorders with vascular origins. Internationally it has been used for frontotemporal dementia as well as early onset in Lewy body dementia and Parkinson's dementia. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs. Unlike many other ergolines, such as ergotamine, nicergoline is not associated with cardiac fibrosis.
It is used for vascular disorders such as cerebral thrombosis and atherosclerosis, arterial blockages in the limbs, Raynaud's disease, vascular migraines, and retinopathy.