nilutamide
Sign in to saveAlso known as Nilandron®, 5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin, Nilutamida, Nilutamidum
Nilutamide, sold under the brand names Nilandron and Anandron, is a nonsteroidal antiandrogen (NSAA) which is used in the treatment of prostate cancer. It has also been studied as a component of feminizing hormone therapy for transgender women and to treat acne and seborrhea in women. It is taken by mouth.
Research
341 papers- Nilutamide.2012
- Nilutamide: an antiandrogen for the treatment of prostate cancer.The Annals of pharmacotherapy · 1997
- Pharmacokinetics and metabolism of nilutamide.Urology · 1991
- Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer.Drugs & aging · 1993
- Efficacy and Safety of Nilutamide in Patients with Metastatic Prostate Cancer who Underwent Orchiectomy: A Systematic Review and Metaanalysis.Current clinical pharmacology · 2019
via PubMed
Wikidata facts
- Mass
- 317.06234
Show 5 more facts
- Commons category
- Nilutamide
- chemical formula
- C₁₂H₁₀F₃N₃O₄
- canonical SMILES
- CC1(C(=O)N(C(=O)N1)C2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)C
- World Health Organisation international non-proprietary name
- nilutamide
- defined daily dose
- 0.3
Sources (7)
via Wikidata · CC0
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Article
20 sectionsContents
- Medical uses
- Prostate cancer
- Transgender hormone therapy
- Skin conditions
- Available forms
- Side effects
- Pharmacology
- Pharmacodynamics
- Antiandrogenic activity
- Cytochrome P450 inhibition
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Generic names
- Brand names
- Availability
- Research
- References
- Further reading
Nilutamide, sold under the brand names Nilandron and Anandron, is a nonsteroidal antiandrogen (NSAA) which is used in the treatment of prostate cancer. It has also been studied as a component of feminizing hormone therapy for transgender women and to treat acne and seborrhea in women. It is taken by mouth.
Side effects in men include breast tenderness and enlargement, feminization, sexual dysfunction, and hot flashes. Nausea, vomiting, visual disturbances, alcohol intolerance, elevated liver enzymes, and lung disease can occur in both sexes. Rarely, nilutamide can cause respiratory failure and liver damage. These unfavorable side effects, along with a number of associated cases of death, have limited the use of nilutamide.