Structure via PubChem · Public domain (PubChem)
nobiletin
Sign in to saveAlso known as 5,6,7,8,3',4'-hexamethoxyflavone, hexamethoxyflavone
Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.
Chemical data
- Formula
- C21H22O8
- Molecular weight
- 402.4 g/mol
- IUPAC name
- 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
- SMILES
- COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC
- InChIKey
- MRIAQLRQZPPODS-UHFFFAOYSA-N
- XLogP
- 3
- Polar surface area
- 81.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
1,226 papers- Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer's Disease and Parkinson's Disease.International journal of molecular sciences · 2019
- Nobiletin Improves D-Galactose-Induced Aging Mice Skeletal Muscle Atrophy by Regulating Protein Homeostasis.Nutrients · 2023
- Nobiletin in Cancer Therapy; Mechanisms and Therapy Perspectives.Current pharmaceutical design · 2023
- Nobiletin Prevents D-Galactose-Induced C2C12 Cell Aging by Improving Mitochondrial Function.International journal of molecular sciences · 2022
- Nobiletin as a chemopreventive natural product against cancer, a comprehensive review.Critical reviews in food science and nutrition · 2023
via PubMed
Wikidata facts
- Subclass of
- flavone
- Mass
- 402.131
Show 6 more facts
- found in taxon
- Citrus japonica
- chemical formula
- C₂₁H₂₂O₈
- canonical SMILES
- COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC
- subject has role
- antioxidant
- has characteristic
- bitterness
- Commons category
- 3',4',5,6,7,8-Hexahydroxyflavone
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Potential pharmacology
- References
- External links
Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.
==Potential pharmacology== Nobiletin was found to potentially inhibit cartilage degradation.
Excerpted from Wikipedia’s “nobiletin” article, available under the CC BY-SA 4.0 licence.