diosmin
Sign in to saveAlso known as diosmetin 7-O-rutinoside, diosmetin 7-neohesperidoside, neodiosmin, 3',5,7-trihydroxy-4'-methoxyflavone 7-rhamnoglucoside, 3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside, diosmine
Diosmin (diosmetin 7-O-rutinoside), a flavone glycoside of diosmetin, is manufactured from citrus fruit peels as a phlebotonic non-prescription dietary supplement used to aid treatment of hemorrhoids or chronic venous diseases, mainly of the legs.
Research
958 papers- Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review.European journal of drug metabolism and pharmacokinetics · 2022
- Diosmin attenuates UUO-induced renal ferroptosis and fibrosis by inhibiting the HIF-1α/FABP4 signaling axis.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2025
- Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2025
- Diosmin prophylaxis reduces gentamicin-induced kidney damage in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2023
- Hepatoprotective effects of diosmin: a narrative review.Naunyn-Schmiedeberg's archives of pharmacology · 2025
via PubMed
Wikidata facts
- Mass
- 608.17412
Show 5 more facts
- chemical formula
- C₂₈H₃₂O₁₅
- World Health Organisation international non-proprietary name
- diosmin
- canonical SMILES
- CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
- isomeric SMILES
- C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
- Commons category
- Diosmin
via Wikidata · CC0
~3 min read
Article
6 sectionsContents
- Uses
- Phlebotonics
- Adverse effects
- Regulatory status
- See also
- References
Diosmin (diosmetin 7-O-rutinoside), a flavone glycoside of diosmetin, is manufactured from citrus fruit peels as a phlebotonic non-prescription dietary supplement used to aid treatment of hemorrhoids or chronic venous diseases, mainly of the legs.
==Uses== Diosmin is a dietary supplement used to aid treatment of hemorrhoids and venous diseases, i.e., chronic venous insufficiency including spider and varicose veins, leg swelling (edema), stasis dermatitis and venous ulcers. The mechanism of action of Diosmin and other phlebotonics is undefined, and clinical evidence of benefit is limited. Diosmin is not recommended for treating the rectal mucosa, skin irritations, or wounds, and should not be used to treat dermatitis, eczema, or urticaria. Diosmin is not recommended for use in children or women during pregnancy. There is moderate-quality evidence that diosmin or other phlebotonics improved leg and ankle swelling and lower leg pain, and low-quality evidence for treating hemorrhoids.