Structure via PubChem · Public domain (PubChem)
fluocinonide
Sign in to saveAlso known as Fluonex®, Lidex®, Fluocinonido, Fluocinonidum
Fluocinonide is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.
Chemical data
- Formula
- C26H32F2O7
- Molecular weight
- 494.5 g/mol
- IUPAC name
- [2-[(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] acetate
- SMILES
- CC(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@]4([C@H]3C[C@@H](C5=CC(=O)C=C[C@@]54C)F)F)O)C)OC(O2)(C)C
- InChIKey
- WJOHZNCJWYWUJD-IUGZLZTKSA-N
- XLogP
- 3.2
- Polar surface area
- 99.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1971
- Admin. routes
- topical
- Indications
- breast carcinoma, skin disease, atopic eczema, psoriasis
via ChEMBL · EBI
Research
302 papers- Fluocinonide.2006
- Impact of Topical Fluocinonide on Oral Lichen Planus Evolution: Randomized Controlled Clinical Trial.Oral diseases · 2025
- Fluocinonide in FAPG base: a review of its therapeutic efficacy in inflammatory dermatoses.Drugs · 1974
- Oral lichen planus: comparative efficacy and treatment costs-a systematic review.BMC oral health · 2022
- Fluocinonide.Nursing times · 2005
via PubMed
Wikidata facts
- Mass
- 494.212
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₆H₃₂F₂O₇
- medical condition treated
- inflammation
- isomeric SMILES
- CC(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@]4([C@H]3C[C@@H](C5=CC(=O)C=C[C@@]54C)F)F)O)C)OC(O2)(C)C
- canonical SMILES
- CC(=O)OCC(=O)C12C(CC3C1(CC(C4(C3CC(C5=CC(=O)C=CC54C)F)F)O)C)OC(O2)(C)C
- Commons category
- Fluocinonide
- legal status (medicine)
- boxed warning
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Veterinary uses
- References
Fluocinonide is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.
A common potential adverse effect is skin atrophy (thinning of the skin).
Excerpted from Wikipedia’s “fluocinonide” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0