alclometasone

Also known as 7alpha-Chloro-16alpha-methylprednisolone, Aclometasone, 7α-Chloro-16α-methylprednisolone, (7alpha,11beta,16alpha)-7-chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.

In the Vinony graph

Within Vinony's link graph, alclometasone is referenced by 274 other articles, and connects out to dermatitis, mometasone furoate and fludrocortisone.

It is catalogued under topics including Drugboxes which contain changes to verified fields, Drugboxes which contain changes to watched fields and Glucocorticoids.

Its subject is documented across 15 Wikipedia language editions.

Chemical data

Formula: C22H29ClO5
Molecular weight: 408.9 g/mol
IUPAC name: (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
SMILES: C[C@@H]1C[C@H]2[C@@H]3[C@@H](CC4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)Cl
InChIKey: FJXOGVLKCZQRDN-PHCHRAKRSA-N
XLogP: 2.2
Polar surface area: 94.8 Å²
H-bond donors: 3
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Molecule type: Small molecule

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 408.17
Has use: medication

Show 5 more facts

medical condition treated: inflammation
chemical formula: C₂₂H₂₉ClO₅
isomeric SMILES: C[C@@H]1C[C@H]2[C@@H]3[C@@H](CC4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)Cl
canonical SMILES: CC1CC2C3C(CC4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)CO)O)C)O)C)Cl
World Health Organisation international non-proprietary name: alclometasone

Sources (2)

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Encyclopedic overview

6 sections

Contents

Medical uses
Contraindications
Side effects
Pharmacology
Formulations
References

Alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.

The prodrug alclometasone dipropionate was originally marketed under the brand name Aclovate by GlaxoSmithKline as a topical cream and ointment. However, generic versions of the drug are available.

Excerpted from Wikipedia’s “alclometasone” article, available under the CC BY-SA 4.0 licence.