alclometasone

Also known as 7alpha-Chloro-16alpha-methylprednisolone, Aclometasone, 7α-Chloro-16α-methylprednisolone, (7alpha,11beta,16alpha)-7-chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.

Chemical data

Formula: C22H29ClO5
Molecular weight: 408.9 g/mol
IUPAC name: (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
SMILES: C[C@@H]1C[C@H]2[C@@H]3[C@@H](CC4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)Cl
InChIKey: FJXOGVLKCZQRDN-PHCHRAKRSA-N
XLogP: 2.2
Polar surface area: 94.8 Å²
H-bond donors: 3
H-bond acceptors: 5
Formal charge: 0

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Drug data · ChEMBL

Molecule type: Small molecule

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 408.17
Has use: medication

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medical condition treated: inflammation
chemical formula: C₂₂H₂₉ClO₅
isomeric SMILES: C[C@@H]1C[C@H]2[C@@H]3[C@@H](CC4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)Cl
canonical SMILES: CC1CC2C3C(CC4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)CO)O)C)O)C)Cl
World Health Organisation international non-proprietary name: alclometasone

Sources (2)

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Encyclopedic overview

6 sections

Contents

Medical uses
Contraindications
Side effects
Pharmacology
Formulations
References

Alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.

The prodrug alclometasone dipropionate was originally marketed under the brand name Aclovate by GlaxoSmithKline as a topical cream and ointment. However, generic versions of the drug are available.

Excerpted from Wikipedia’s “alclometasone” article, available under the CC BY-SA 4.0 licence.

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