amcinonide
Sign in to saveAlso known as CL-34699, Cyclocort®, Triamcinolonacetatcyclopentanonid
Amcinonide (trade name Cyclocort) is a topical glucocorticoid used to treat itching, redness and swelling associated with several dermatologic conditions such as atopic dermatitis and allergic contact dermatitis. Amcinonide can also be classified as a multi-functional small molecule corticosteroid, which has been approved by the FDA and is currently marketed as an ointment, lotion, or cream. It acts as both a transcription factor for responses to glucocorticoids and modulator for other transcription factors while also regulating phospholipase A2 activity.
Research
56 papers- Amcinonide.2006
- Contact allergy to amcinonide.Contact dermatitis · 1986
- Amcinonide vs. betamethasone dipropionate ointments in the treatment of psoriasis.Cutis · 1985
- Allergic contact dermatitis from amcinonide.Contact dermatitis · 1985
- Contact dermatitis from amcinonide.Contact dermatitis · 1987
via PubMed
Wikidata facts
- Mass
- 502.237
Show 4 more facts
- chemical formula
- C₂₈H₃₅FO₇
- canonical SMILES
- CC(=O)OCC(=O)C12C(CC3C1(CC(C4(C3CCC5=CC(=O)C=CC54C)F)O)C)OC6(O2)CCCC6
- isomeric SMILES
- CC(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@]4([C@H]3CCC5=CC(=O)C=C[C@@]54C)F)O)C)OC6(O2)CCCC6
- Commons category
- Amcinonide
Sources (2)
via Wikidata · CC0
~11 min read
Article
11 sectionsContents
- Medical Uses
- Dermatitis, Psoriasis, & Eczema
- Adverse Effects
- Pharmacology
- Mechanism of Action
- Metabolism & Elimination
- History
- Research & Clinical Trials
- Commercialization
- Regulatory
- References
Amcinonide (trade name Cyclocort) is a topical glucocorticoid used to treat itching, redness and swelling associated with several dermatologic conditions such as atopic dermatitis and allergic contact dermatitis. Amcinonide can also be classified as a multi-functional small molecule corticosteroid, which has been approved by the FDA and is currently marketed as an ointment, lotion, or cream. It acts as both a transcription factor for responses to glucocorticoids and modulator for other transcription factors while also regulating phospholipase A2 activity.
== Medical Uses == Corticosteroids applied topically are used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, particularly dermatitis, eczema, and psoriasis. Cyclocort's active ingredient is Amcinonide, with inactive ingredients including petrolatum, benzyl alcohol, sorbitol, butylated hydroxyanisole, propyl gallate, citric acid, glycerin, and/ or propylene glycol. The specific inactive ingredients used depend on the dosage form (ointment, area, or lotion) and help the product retain its chemical and physical integrity while increasing the shelf-life.
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