OLR1

Also known as CLEC8A, LOX1, LOXIN, SCARE1, SLOX1, oxidized low density lipoprotein receptor 1

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.

Gene data

OLR1

Name: oxidized low density lipoprotein receptor 1
Type: protein-coding
Position: 10,156,240–10,172,143 (−)
Aliases: CLEC8A, LOX1, LOXIN, SCARE1, SLOX1
Ensembl: ENSG00000173391
RefSeq RNA: NM_001172632.2, NM_001172633.2, NM_002543.4, XM_047428907.1, XM_047428908.1
RefSeq protein: NP_001166103.1, NP_001166104.1, NP_002534.1, XP_047284863.1, XP_047284864.1

This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010].

Gene Ontology

Biological process

proteolysis leukocyte cell-cell adhesion blood circulation vesicle-mediated transport lipoprotein metabolic process

Molecular function

low-density lipoprotein particle receptor activity protein binding identical protein binding

Cellular component

extracellular region plasma membrane plasma membrane plasma membrane plasma membrane membrane specific granule membrane signaling receptor complex

Pathways

PPAR signaling pathway - Homo sapiens (human)Phagosome - Homo sapiens (human)Lipid and atherosclerosis - Homo sapiens (human)Hemostasis Innate Immune System Immune System Cell surface interactions at the vascular wall Neutrophil degranulation PPAR signaling pathway

via MyGene.info

Gene · Ensembl

oxidized low density lipoprotein receptor 1

Symbol: OLR1
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:10,156,240-10,172,143
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~2 min read

Encyclopedic overview

4 sections

Contents

Function
Clinical significance
References
Further reading

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.

LOX-1 is the main receptor for oxidized LDL on endothelial cells, macrophages, smooth muscle cells, and other cell types. But minimally oxidized LDL is more readily recognized by the TLR4 receptor, and highly oxidized LDL is more readily recognized by the CD36 receptor.

Excerpted from Wikipedia’s “OLR1” article, available under the CC BY-SA 4.0 licence.