Structure via PubChem · Public domain (PubChem)
olutasidenib
Sign in to saveAlso known as Rezlidhia, 5-[[(1S)-1-(6-chloro-2-oxo-1H-quinolin-3-yl)ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile
Olutasidenib, sold under the brand name Rezlidhia, is an anticancer medication used to treat relapsed or refractory acute myeloid leukemia with a susceptible IDH1 mutation. Olutasidenib is an isocitrate dehydrogenase-1 (IDH1) inhibitor. It is taken by mouth.
Chemical data
- Formula
- C18H15ClN4O2
- Molecular weight
- 354.8 g/mol
- IUPAC name
- 5-[[(1S)-1-(6-chloro-2-oxo-1H-quinolin-3-yl)ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile
- SMILES
- C[C@@H](C1=CC2=C(C=CC(=C2)Cl)NC1=O)NC3=CC=C(N(C3=O)C)C#N
- InChIKey
- NEQYWYXGTJDAKR-JTQLQIEISA-N
- XLogP
- 2.5
- Polar surface area
- 85.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 354.0883534000001
Show 4 more facts
- isomeric SMILES
- C[C@@H](C1=CC2=C(C=CC(=C2)Cl)NC1=O)NC3=CC=C(N(C3=O)C)C#N
- chemical formula
- C₁₈H₁₅ClN₄O₂
- canonical SMILES
- CC(C1=Cc2cc(ccc2NC1=O)Cl)NC3=CC=C(N(C3=O)C)C#N
- legal status (medicine)
- boxed warning
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Society and culture
- Names
- References
- Further reading
- External links
{{Infobox drug | image = Olutasidenib.svg | image_class = skin-invert-image | width = | alt = | caption =
| pronounce = | tradename = Rezlidhia | Drugs.com = | MedlinePlus = | DailyMedID = Olutasidenib | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = | ATC_prefix = L01 | ATC_suffix = XM03 | ATC_supplemental =
Excerpted from Wikipedia’s “olutasidenib” article, available under the CC BY-SA 4.0 licence.