OTULIN
Sign in to saveAlso known as FAM105B, GUM, OTU deubiquitinase with linear linkage specificity, AIPDS
Family with sequence similarity 105, member B is a protein in humans that is encoded by the FAM105B gene.
Gene data
OTULIN- Name
- OTU deubiquitinase with linear linkage specificity
- Type
- protein-coding
- Aliases
- AIPDS, AIPDSA, FAM105B, GUM, IMD107
This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients. [provided by RefSeq, Sep 2016].
via MyGene.info
Gene · Ensembl
OTU deubiquitinase with linear linkage specificity
- Symbol
- OTULIN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:14,664,664-14,716,529
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 106591
- exact match
- identifiers.org/ncbigene/90268
- genomic end
- 14699850
- genomic start
- 14664773
- cytogenetic location
- 5p15.2
Sources (3)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Family with sequence similarity 105, member B is a protein in humans that is encoded by the FAM105B gene.
== References ==