OTULIN

Also known as FAM105B, GUM, OTU deubiquitinase with linear linkage specificity, AIPDS

Family with sequence similarity 105, member B is a protein in humans that is encoded by the FAM105B gene.

In the Vinony graph

Vinony's link graph records 2 inbound references to OTULIN, and connects out to human chromosome 5, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 5.

Vinony links it to 5 Wikipedia language editions.

Gene data

OTULIN

Name: OTU deubiquitinase with linear linkage specificity
Type: protein-coding
Position: 14,664,664–14,716,529 (+)
Aliases: AIPDS, AIPDSA, FAM105B, GUM, IMD107
Ensembl: ENSG00000154124
RefSeq RNA: NM_001445753.1, NM_001445754.1, NM_001445755.1, NM_138348.6, XM_011514151.3
RefSeq protein: NP_001432682.1, NP_001432683.1, NP_001432684.1, NP_612357.4, XP_011512453.1

This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients. [provided by RefSeq, Sep 2016].