PADI1
Sign in to saveAlso known as HPAD10, PAD1, PDI, PDI1, peptidyl arginine deiminase 1
Peptidyl arginine deiminase, type I, also known as PADI1, is a protein which in humans is encoded by the PADI1 gene.
In the Vinony graph
Vinony's link graph records 6 inbound references to PADI1, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Vinony links it to 5 Wikipedia language editions.
Gene data
PADI1- Name
- peptidyl arginine deiminase 1
- Type
- protein-coding
- Position
- 17,205,120–17,246,007 (+)
- Aliases
- HPAD10, PAD1, PDI, PDI1
- Ensembl
- ENSG00000281459
- RefSeq RNA
- NM_013358.3, XM_011541307.3, XM_017001101.2, XM_017001102.2, XM_017001103.3
- RefSeq protein
- NP_037490.2, XP_011539609.1, XP_016856590.1, XP_016856591.1, XP_016856592.1
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008].
Gene Ontology
Molecular function
via MyGene.info
Gene · Ensembl
peptidyl arginine deiminase 1
- Symbol
- PADI1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:17,205,120-17,246,007
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 7881
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/29943
- chromosome
- human chromosome 1
- genomic start
- 17205128
- genomic end
- 17246007
- cytogenetic location
- 1p36.13
- expressed in
- rectum
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Peptidyl arginine deiminase, type I, also known as PADI1, is a protein which in humans is encoded by the PADI1 gene.
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.
Excerpted from Wikipedia’s “PADI1” article, available under the CC BY-SA 4.0 licence.