PAM

Name

peptidylglycine alpha-amidating monooxygenase

Type

protein-coding

Aliases

PAL, PAM-1, PHM

This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].

via MyGene.info

Gene · Ensembl

peptidylglycine alpha-amidating monooxygenase

Symbol

PAM

Biotype

Protein coding

Organism

Homo sapiens

Location

5:102,753,981-103,031,149

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein PAM PDB 1opm.png

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