Structure via PubChem · Public domain (PubChem)
pargyline
Sign in to saveAlso known as Eutonyl®, Eutonyl, A-19120, MO-911, Eutron
Pargyline, sold under the brand name Eutonyl among others, is a monoamine oxidase inhibitor (MAOI) medication which has been used to treat hypertension (high blood pressure) but is no longer marketed. It has also been studied as an antidepressant, but was never licensed for use in the treatment of depression. The drug is taken by mouth.
Chemical data
- Formula
- C11H13N
- Molecular weight
- 159.23 g/mol
- IUPAC name
- N-benzyl-N-methylprop-2-yn-1-amine
- SMILES
- CN(CC#C)CC1=CC=CC=C1
- InChIKey
- DPWPWRLQFGFJFI-UHFFFAOYSA-N
- XLogP
- 2.1
- Polar surface area
- 3.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- oral
- Indications
- hypertension
via ChEMBL · EBI
Research
3,650 papersvia PubMed
Wikidata facts
- Mass
- 159.104799
- Has use
- medication
Show 4 more facts
- chemical formula
- C₁₁H₁₃N
- canonical SMILES
- CN(CC#C)CC1=CC=CC=C1
- subject has role
- monoamine oxidase inhibitor
- Commons category
- Pargyline
via Wikidata · CC0
~10 min read
Encyclopedic overview
14 sectionsContents
- Medical uses
- Side effects
- Interactions
- Pharmacology
- Pharmacodynamics
- Monoamine oxidase inhibition
- Other actions
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Names
- Research
- References
Pargyline, sold under the brand name Eutonyl among others, is a monoamine oxidase inhibitor (MAOI) medication which has been used to treat hypertension (high blood pressure) but is no longer marketed. It has also been studied as an antidepressant, but was never licensed for use in the treatment of depression. The drug is taken by mouth.
Side effects of pargyline include orthostatic hypotension among others. It has the potential for serious food and drug interactions with sympathomimetic agents like tyramine that can result in hypertensive crisis. Pargyline acts as a non-selective and irreversible inhibitor of the monoamine oxidases MAO-A and MAO-B. The exact mechanism of the hypotensive effects of pargyline and other MAOIs is unclear. Structurally, pargyline is a benzylamine derivative and is related to selegiline and clorgyline.
Excerpted from Wikipedia’s “pargyline” article, available under the CC BY-SA 4.0 licence.