PCBP4

Also known as CBP, LIP4, MCG10, poly(rC) binding protein 4

Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to PCBP4, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 3.

Vinony links it to 5 Wikipedia language editions.

Gene data

PCBP4

Name: poly(rC) binding protein 4
Type: protein-coding
Position: 51,957,448–51,974,630 (−)
Aliases: CBP, LIP4, MCG10
Ensembl: ENSG00000090097
RefSeq RNA: NM_001174100.2, NM_001363885.1, NM_020418.4, NM_033008.3, NM_033009.1
RefSeq protein: NP_001167571.1, NP_001350814.1, NP_065151.2, NP_127501.1, NP_127503.1

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II regulation of gene expression regulation of mRNA stability negative regulation of mRNA splicing, via spliceosome regulation of mRNA metabolic process

Molecular function

nucleic acid binding RNA binding RNA binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding

Cellular component

nucleus cytoplasm cytoplasm cytosol cytosol

Pathways

Cell Cycle Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Transcription of Cell Cycle Genes TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Transcriptional activation of p53 responsive genes p53-Dependent G1 DNA Damage Response p53-Dependent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Cell Cycle Checkpoints

via MyGene.info

Gene · Ensembl

poly(rC) binding protein 4

Symbol: PCBP4
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:51,957,448-51,974,630
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 56926
exact match: identifiers.org/ncbigene/57060
found in taxon: Homo sapiens
genomic end: 52002426
genomic start: 51991470
chromosome: human chromosome 3
cytogenetic location: 3p21.2
expressed in: amygdala

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References
Further reading

Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene.

This gene encodes a member of the KH domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.

Excerpted from Wikipedia’s “PCBP4” article, available under the CC BY-SA 4.0 licence.