PCGF1
Sign in to saveAlso known as 2010002K04Rik, NSPC1, RNF3A-2, RNF68, polycomb group ring finger 1
Polycomb group RING finger protein 1, PCGF1, also known as NSPC1 or RNF68 is a RING finger domain protein that in humans is encoded by the PCGF1 gene.
Gene data
PCGF1- Name
- polycomb group ring finger 1
- Type
- protein-coding
- Aliases
- 2010002K04Rik, NSPC1, RNF3A-2, RNF68
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008].
via MyGene.info
Gene · Ensembl
polycomb group ring finger 1
- Symbol
- PCGF1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:74,505,041-74,508,361
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 13090
- exact match
- identifiers.org/ncbigene/84759
- genomic end
- 74507695
- genomic start
- 74732170
- cytogenetic location
- 2p13.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Polycomb group RING finger protein 1, PCGF1, also known as NSPC1 or RNF68 is a RING finger domain protein that in humans is encoded by the PCGF1 gene.
PCGF1 is a component defining the non-canonical polycomb repressive complex 1.1 (ncPRC1) interacting with RING1A/B, RYBP, BCOR and KDM2B. PCGF1-BCOR assembles via the ubiquitin-like RAWUL domain of PCGF1 and is recruited on the chromatin at KDM2B sites. Within the PRC1-like complex, PCGF1 regulates RING1B ubiquitin ligase activity that catalyzes the ubiquitination of Lys119 on histone H2A, which then leads to recruitment of PRC2 and H3K27me3 to effectively initiate a polycomb domain and mediate gene repression.