pemetrexed

Also known as Alimta®, LY-231514

Pemetrexed, sold under the brand name Alimta among others, is a chemotherapy medication for the treatment of pleural mesothelioma and non-small cell lung cancer (NSCLC).

Key facts

Drug.Verifiedfields: changed
Drug.verifiedrevid: 464197624
Drug.image: Pemetrexed.svg
Drug.image_class: skin-invert-image
Drug.image2: Pemetrexed ball-and-stick.png
Drug.image_class2: bg-transparent
Drug.tradename: Alimta, Pemfexy, Ciambra, others
Drug.DailyMedID: Pemetrexed
Drug.pregnancy_AU: D
Drug.routes_of_administration: Intravenous
Drug.ATC_prefix: L01
Drug.ATC_suffix: BA04
Drug.legal_AU: S4
Drug.legal_UK: POM
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.bioavailability: NA
Drug.protein_bound: 81%

via Wikipedia infobox

Chemical data

Formula: C20H21N5O6
Molecular weight: 427.4 g/mol
IUPAC name: (2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
SMILES: C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O
InChIKey: WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
XLogP: 0.2
Polar surface area: 187 Å²
H-bond donors: 6
H-bond acceptors: 6
Formal charge: 0

via PubChem

Wikidata facts

Mass: 427.149183

Show 6 more facts

chemical formula: C₂₀H₂₁N₅O₆
World Health Organisation international non-proprietary name: pemetrexed
isomeric SMILES: C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O
canonical SMILES: C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)O)C(=O)O
stylized name: PEMEtrexed
Commons category: Pemetrexed

Sources (9)

via Wikidata · CC0

~5 min read

Article

11 sections

Contents

Medical use
Carboplatin
Supplementation
Drug interaction
Mechanism of action
Society and culture
Economics
Brand names
Research
References
External links

{{Infobox drug | Verifiedfields = changed | verifiedrevid = 464197624 | image = Pemetrexed.svg | image_class = skin-invert-image | image2 = Pemetrexed ball-and-stick.png | image_class2 = bg-transparent