pemirolast

Also known as Alamast®, Alegysal®, BMY-26517, Pemirolastum, Pemirox

Pemirolast (INN) is a mast cell stabilizer used as an anti-allergic drug therapy. It is marketed under the tradenames Alegysal and Alamast.

In the Vinony graph

Within Vinony's link graph, pemirolast is referenced by 5 other articles, and connects out to asthma, allergy and digital object identifier.

It is catalogued under topics including Drugboxes which contain changes to verified fields, Drugs not assigned an ATC code and Drugs with non-standard legal status.

Its subject is documented across 18 Wikipedia language editions.

Chemical data

Formula: C10H8N6O
Molecular weight: 228.21 g/mol
IUPAC name: 9-methyl-3-(2H-tetrazol-5-yl)pyrido[1,2-a]pyrimidin-4-one
SMILES: CC1=CC=CN2C1=NC=C(C2=O)C3=NNN=N3
InChIKey: HIANJWSAHKJQTH-UHFFFAOYSA-N
XLogP: -0.3
Polar surface area: 87.1 Å²
H-bond donors: 1
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1999
Admin. routes: topical
Indications: Abdominal Aortic Aneurysm, asthma, Becker muscular dystrophy, Duchenne muscular dystrophy

via ChEMBL · EBI

Research

67 papers

Pemirolast.2006
Pemirolast reduces cisplatin-induced kaolin intake in rats.European journal of pharmacology · 2011
Pemirolast potassium 0.1% ophthalmic solution is an effective treatment for allergic conjunctivitis: a pooled analysis of two prospective, randomized, double-masked, placebo-controlled, phase III studies.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2002
In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis.Drug design, development and therapy · 2021
Suppressive activity of pemirolast potassium, an antiallergic drug, on glomerulonephritis. Studies in glomerulonephritis model rats and in patients with chronic glomerulonephritis concurrently affected by allergic rhinitis.Arzneimittel-Forschung · 2008

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 228.075959
Has use: medication

Show 4 more facts

chemical formula: C₁₀H₈N₆O
canonical SMILES: CC1=CC=CN2C1=NC=C(C2=O)C3=NNN=N3
subject has role: calcium channel blocker
has characteristic: bitterness

Sources (2)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
External links

Pemirolast (INN) is a mast cell stabilizer used as an anti-allergic drug therapy. It is marketed under the tradenames Alegysal and Alamast.

Clinical trials studying treatments for allergic conjunctivitis have found that an ophthalmic solution containing levocabastine with pemirolast potassium may be more effective in alleviating symptoms than levocabastine alone.

Excerpted from Wikipedia’s “pemirolast” article, available under the CC BY-SA 4.0 licence.