Structure via PubChem · Public domain (PubChem)
pentostatin
Sign in to saveAlso known as 2'-deoxycoformycin, deoxycoformycin, Nipent®, Pentostatine, Co-vidarabine, Pentostatina, Pentostatinum
Pentostatin (or 2′-deoxycoformycin, trade name Nipent, manufactured by SuperGen) is an anticancer chemotherapeutic drug.
Key facts
- Drug.H
- 16
- Drug.N
- 4
- Drug.O
- 4
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464198455
- Drug.IUPAC_name
- (R)-3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
- Drug.image
- Pentostatin structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Pentostatin ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200
- Drug.tradename
- Nipent
- Drug.MedlinePlus
- a692004
- Drug.pregnancy_US
- D
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C11H16N4O4
- Molecular weight
- 268.27 g/mol
- IUPAC name
- (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
- SMILES
- C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC=NC[C@H]3O)CO)O
- InChIKey
- FPVKHBSQESCIEP-JQCXWYLXSA-N
- XLogP
- -2.1
- Polar surface area
- 112 Ų
- H-bond donors
- 4
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1991
- Admin. routes
- parenteral
- Indications
- neoplasm, chronic lymphocytic leukemia, leukemia, lymphoma
via ChEMBL · EBI
Research
1,217 papersvia PubMed
Wikidata facts
- Subclass of
- alkaloid
- Mass
- 268.117
- Has use
- medication
Show 9 more facts
- chemical formula
- C₁₁H₁₆N₄O₄
- World Health Organisation international non-proprietary name
- pentostatin
- medical condition treated
- chronic lymphocytic leukemia
- isomeric SMILES
- C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC=NC[C@H]3O)CO)O
- canonical SMILES
- C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O
- Commons category
- Pentostatin
- physically interacts with
- Adenosine deaminase
- legal status (medicine)
- boxed warning
- significant drug interaction
- (RS)-cyclophosphamide
via Wikidata · CC0
~4 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Mechanism of action
- Production
- Fermentation
- Total synthesis
- Natural occurrence
- Natural analogues
- References
Pentostatin (or 2′-deoxycoformycin, trade name Nipent, manufactured by SuperGen) is an anticancer chemotherapeutic drug.
== Medical uses == Pentostatin is used to treat hairy cell leukemia. It is given by intravenous infusion once every two weeks for three to six months.
Excerpted from Wikipedia’s “pentostatin” article, available under the CC BY-SA 4.0 licence.