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perzinfotel
Sign in to savePerzinfotel (EAA-090) is a drug which acts as a potent NMDA antagonist. It has neuroprotective effects and has been investigated for the treatment of stroke, but lacks analgesic effects. Nevertheless, it shows a good safety profile compared to older drugs, although further development of this drug has been discontinued.
Chemical data
- Formula
- C9H13N2O5P
- Molecular weight
- 260.18 g/mol
- IUPAC name
- 2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethylphosphonic acid
- SMILES
- C1CNC2=C(C(=O)C2=O)N(C1)CCP(=O)(O)O
- InChIKey
- BDABGOLMYNHHTR-UHFFFAOYSA-N
- XLogP
- -1.6
- Polar surface area
- 107 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Has part
- hydrogen
- Mass
- 260.056
Show 3 more facts
- chemical formula
- C₉H₁₃N₂O₅P
- canonical SMILES
- C1CNC2=C(C(=O)C2=O)N(C1)CCP(=O)(O)O
- Commons category
- Perzinfotel
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Perzinfotel (EAA-090) is a drug which acts as a potent NMDA antagonist. It has neuroprotective effects and has been investigated for the treatment of stroke, but lacks analgesic effects. Nevertheless, it shows a good safety profile compared to older drugs, although further development of this drug has been discontinued.
Prodrugs were developed since the oral bioavailability of perzinfotel is only around 3-5%.
Excerpted from Wikipedia’s “perzinfotel” article, available under the CC BY-SA 4.0 licence.