Structure via PubChem · Public domain (PubChem)
phentermine
Sign in to saveAlso known as α,α-dimethylphenethylamine, alpha,alpha-dimethylphenethylamine
Phentermine, sold under the brand name Adipex-P among others, is a medication used together with diet and exercise to treat obesity. It is available by itself or as the combination phentermine/topiramate. Phentermine is taken by mouth.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 477171245
- Drug.image
- Phentermine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200px
- Drug.image2
- PHENTERMINE 3D-BALL-AND-STICK.png
- Drug.tradename
- Adipex-P, Ionamin, Suprenza, others
- Drug.MedlinePlus
- a682187
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth
- Drug.addiction_liability
- Low
- Drug.dependency_liability
- Physical: Not typical Psychological: Moderate
- Drug.class
- Psychostimulant; Appetite suppressant; Norepinephrine–dopamine releasing agent
- Drug.ATC_prefix
- A08
- Drug.ATC_suffix
- AA01
- Drug.legal_AU
- S4
- Drug.legal_BR
- B2
- Drug.legal_CA
- Schedule IV
via Wikipedia infobox
Chemical data
- Formula
- C10H15N
- Molecular weight
- 149.23 g/mol
- IUPAC name
- 2-methyl-1-phenylpropan-2-amine
- SMILES
- CC(C)(CC1=CC=CC=C1)N
- InChIKey
- DHHVAGZRUROJKS-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 26 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Research
1,848 papers- Phentermine/Topiramate: Pediatric First Approval.Paediatric drugs · 2022
- Synthesis of Phentermine and its Derivatives.Current organic synthesis · 2024
- Phentermine in the Modern Era of Obesity Pharmacotherapy: Does It Still Have a Role in Treatment?Current obesity reports · 2024
- Safety and Effectiveness of Longer-Term Phentermine Use: Clinical Outcomes from an Electronic Health Record Cohort.Obesity (Silver Spring, Md.) · 2019
- Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial.Lancet (London, England) · 2011
via PubMed
Wikidata facts
- Subclass of
- anorectic
- Has part
- carbon
- Mass
- 149.120449
- Has use
- medication
Show 8 more facts
- defined daily dose
- 15
- chemical formula
- C₁₀H₁₅N
- significant drug interaction
- tranylcypromine
- medical condition treated
- obesity
- canonical SMILES
- CC(C)(CC1=CC=CC=C1)N
- World Health Organisation international non-proprietary name
- phentermine
- subject has role
- anorectic
- Commons category
- Phentermine
via Wikidata · CC0
~12 min read
Encyclopedic overview
21 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Interactions
- Pharmacology
- Pharmacodynamics
- Monoamine releasing agent
- Other actions
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Elimination
- History
- Chemistry
- Derivatives
- Society and culture
- Etymology
- Brand names
- References
- External links
Phentermine, sold under the brand name Adipex-P among others, is a medication used together with diet and exercise to treat obesity. It is available by itself or as the combination phentermine/topiramate. Phentermine is taken by mouth.
Common side effects include a fast heart beat, high blood pressure, trouble sleeping, dizziness, and restlessness. Serious side effects may include abuse, but do not include pulmonary hypertension or valvular heart disease, as the latter complications were caused by the fenfluramine component of the "fen-phen" combination. Phentermine is a norepinephrine and dopamine releasing agent (NDRA) and produces stimulant, rewarding, and appetite suppressant effects. Chemically, it is a substituted amphetamine.
Excerpted from Wikipedia’s “phentermine” article, available under the CC BY-SA 4.0 licence.