prosultiamine
Sign in to saveProsultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B1 deficiency. It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.
Wikidata facts
- Mass
- 356.134
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- Commons category
- Prosultiamine
- chemical formula
- C₁₅H₂₄N₄O₂S₂
- canonical SMILES
- CCCSSC(=C(C)N(CC1=CN=C(N=C1N)C)C=O)CCO
- isomeric SMILES
- CCCSS/C(=C(\C)/N(CC1=CN=C(N=C1N)C)C=O)/CCO
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Encyclopedic overview
3 sectionsContents
- Research
- See also
- References
Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B1 deficiency. It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.
==Research== It has been studied as a potential treatment for infection with human T-lymphotropic virus (HTLV), since it has been shown to reduce viral load and symptoms.
Excerpted from Wikipedia’s “prosultiamine” article, available under the CC BY-SA 4.0 licence.