Structure via PubChem · Public domain (PubChem)
prosultiamine
Sign in to saveProsultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B1 deficiency. It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.
In the Vinony graph
Within Vinony's link graph, prosultiamine is referenced by 94 other articles, and connects out to Japan, mouth and International Standard Book Number.
Vinony files it under Aminopyrimidines, Chemical pages without DrugBank identifier and Drugs not assigned an ATC code.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C15H24N4O2S2
- Molecular weight
- 356.5 g/mol
- IUPAC name
- N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(propyldisulfanyl)pent-2-en-2-yl]formamide
- SMILES
- CCCSS/C(=C(\C)/N(CC1=CN=C(N=C1N)C)C=O)/CCO
- InChIKey
- UDCIYVVYDCXLSX-SDNWHVSQSA-N
- XLogP
- 1.1
- Polar surface area
- 143 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 356.134
Show 4 more facts
- Commons category
- Prosultiamine
- chemical formula
- C₁₅H₂₄N₄O₂S₂
- canonical SMILES
- CCCSSC(=C(C)N(CC1=CN=C(N=C1N)C)C=O)CCO
- isomeric SMILES
- CCCSS/C(=C(\C)/N(CC1=CN=C(N=C1N)C)C=O)/CCO
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Research
- See also
- References
Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B1 deficiency. It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.
==Research== It has been studied as a potential treatment for infection with human T-lymphotropic virus (HTLV), since it has been shown to reduce viral load and symptoms.
Excerpted from Wikipedia’s “prosultiamine” article, available under the CC BY-SA 4.0 licence.