protamine
Sign in to saveProtamines are small, arginine-rich, nuclear proteins that replace histones late in the haploid phase of spermatogenesis and are believed essential for sperm head condensation via genomic DNA compaction and stabilization. They may allow for denser packaging of DNA in the spermatozoon than histones, but they must be decompressed before the genetic data can be used for protein synthesis. However, part of the sperm's genome is packaged by histones (10-15% in humans and other primates) thought to bind genes that are essential for early embryonic development.
Key facts
- Protein.Name
- Protamine 2
- Protein.HGNCid
- 9448
- Protein.Symbol
- PRM2
- Protein.EntrezGene
- 5620
- Protein.OMIM
- 182890
- Protein.RefSeq
- NM_002762
- Protein.UniProt
- P04554
- Protein.Chromosome
- 16
- Protein.Arm
- p
- Protein.Band
- 13.13
- Protein family.Symbol
- Protamine_P2
- Protein family.Name
- Protamine P2
- Protein family.Pfam
- PF00841
- Protein family.InterPro
- IPR000492
- Protein family.PROSITE
- PDOC00047
via Wikipedia infobox
Research
12,260 papers- Anticoagulant and side-effects of protamine in cardiac surgery: a narrative review.British journal of anaesthesia · 2018
- Protamine--antagonist to heparin.Canadian Medical Association journal · 1973
- Protamine: a review of its toxicity.Anesthesia and analgesia · 1985
- Protamine alterations in human spermatozoa.Advances in experimental medicine and biology · 2014
- Protamine 2 precursors and processing.Protein and peptide letters · 2011
via PubMed
~8 min read
Article
10 sectionsContents
- Spermatogenesis
- Medical uses
- Species distribution and isoforms
- Mammals
- Fish
- Sequence
- Structure
- See also
- References
- External links
Protamines are small, arginine-rich, nuclear proteins that replace histones late in the haploid phase of spermatogenesis and are believed essential for sperm head condensation via genomic DNA compaction and stabilization. They may allow for denser packaging of DNA in the spermatozoon than histones, but they must be decompressed before the genetic data can be used for protein synthesis. However, part of the sperm's genome is packaged by histones (10-15% in humans and other primates) thought to bind genes that are essential for early embryonic development.
Protamine and protamine-like (PL) proteins are collectively known as the sperm-specific nuclear basic proteins (SNBPs). The PL proteins are intermediate in structure between protamine and Histone H1. The C-terminal domain of PL could be the precursor of vertebrate protamine.