proteomics

300px|thumb|right|Robotic preparation of MALDI [[mass spectrometry samples on a sample carrier]]

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Commons category: Proteomics

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~42 min read

Article

43 sections

Contents

History and etymology
Complexity of the problem
Post-translational modifications
Phosphorylation
Ubiquitination
Additional modifications
Distinct proteins are made under distinct settings
Limitations of genomics and proteomics studies
Methods of studying proteins
Protein detection with antibodies (immunoassays)
Antibody-free protein detection
Detection methods
Separation methods
Hybrid technologies
Current research methodologies
High-throughput proteomic technologies
Mass spectrometry and protein profiling
Affinity proteomics
Protein chips
Reverse-phased protein microarrays
Protein Detection via Bioorthogonal Chemistry
Practical applications
Drug discovery
Interaction proteomics and protein networks
Expression proteomics
Biomarkers
Proteogenomics
Structural proteomics
Bioinformatics for proteomics (proteome informatics)
Protein identification
Protein structure
Post-translational modifications
Computational methods in studying protein biomarkers
Emerging trends
Systems biology
Human plasma proteome
Journals
See also
Protein databases
Research centers
References
Bibliography
External links

300px|thumb|right|Robotic preparation of MALDI [[mass spectrometry samples on a sample carrier]]

Proteomics is the large-scale study of proteins. It is an interdisciplinary domain that has benefited greatly from the genetic information of various genome projects, including the Human Genome Project. It covers the exploration of proteomes from the overall level of protein composition, structure, and activity, and is an important component of functional genomics. The proteome is the entire set of proteins produced or modified by an organism or system.