Protriptylin
Sign in to saveAlso known as MK-240, N-methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine, 7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene, 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene, amimetilina, 3-(5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine, N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
Arzneistoff
Key facts
- Drug.ChEMBL
- 668
- Drug.excretion
- Urine: 50%Feces: minor
- Drug.verifiedrevid
- 464375600
- Drug.IUPAC_name
- 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
- Drug.image
- Protriptyline.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200px
- Drug.caption
- Above: molecular structure of protriptyline Below: 3D representation of a protriptyline molecule
- Drug.image2
- Protripyline 3D.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Vivactyl, others
- Drug.MedlinePlus
- a604025
- Drug.pregnancy_US
- C
- Drug.legal_BR
- C1
- Drug.legal_status
- Rx-only
- Drug.routes_of_administration
- Oral
- Drug.bioavailability
- 77–93%
- Drug.protein_bound
- 92%
via Wikipedia infobox
Research
420 papers- Protriptyline.2006
- Protriptyline.2012
- Protriptyline.2026
- Protriptyline kinetics.Clinical pharmacology and therapeutics · 1978
- Protriptyline, a tricyclic antidepressant, inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells.Acta biochimica et biophysica Sinica · 2020
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 263.1674
- Has use
- medication
Show 8 more facts
- chemical formula
- C₁₉H₂₁N
- significant drug interaction
- tranylcypromine
- World Health Organisation international non-proprietary name
- protriptyline
- canonical SMILES
- CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13
- subject has role
- tricyclic antidepressant
- defined daily dose
- 30
- physically interacts with
- solute carrier family 6 member 4
- Commons category
- Protriptyline
Sources (3)
via Wikidata · CC0
Article · Deutsch
Protriptylin (Handelsnamen: Vivactil®, Concordin®) ist ein Arzneistoff aus der Gruppe der trizyklischen Antidepressiva. Es hemmt ähnlich stark wie Desipramin die Wiederaufnahme des Neurotransmitters Noradrenalin, ohne dabei nennenswerte sedierende Eigenschaften zu haben. Protriptylin wirkt zudem als FIASMA (funktioneller Hemmer der sauren Sphingomyelinase). Der Wirkstoff wurde 1962 von Merck & Co. patentiert. Verwendet wird das Hydrochlorid.
Abstract from DBpedia / Wikipedia · CC BY-SA