PRPF8
Sign in to saveAlso known as pre-mRNA processing factor 8, HPRP8, PRP8, PRPC8, RP13, SNRNP220
Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene.
Gene data
PRPF8- Name
- pre-mRNA processing factor 8
- Type
- protein-coding
- Position
- 1,650,624–1,684,909 (−)
- Aliases
- HPRP8, PRP8, PRPC8, RP13, SNRNP220
- Ensembl
- ENSG00000274442
- RefSeq RNA
- NM_006445.4, XM_024450537.2, XM_054314722.1, XM_054329197.1
- RefSeq protein
- NP_006436.3, XP_024306305.1, XP_054170697.1, XP_054185172.1
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
pre-mRNA processing factor 8
- Symbol
- PRPF8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR17_1_CTG2:80,657-114,910
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PRPF8 PDB 3E9L.png
Show 7 more facts
- HomoloGene ID
- 4706
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10594
- chromosome
- human chromosome 17
- genomic start
- 1553923
- genomic end
- 1684867
- cytogenetic location
- 17p13.3
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene.
== Function ==
Excerpted from Wikipedia’s “PRPF8” article, available under the CC BY-SA 4.0 licence.