PYCARD
Sign in to saveAlso known as ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing
PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene. It is localized mainly in the nucleus of monocytes and macrophages. In case of pathogen infection, however, it relocalizes rapidly to the cytoplasm, perinuclear space, endoplasmic reticulum and mitochondria and it is a key adaptor protein in activation of the inflammasome.
Gene data
PYCARD- Name
- PYD and CARD domain containing
- Type
- protein-coding
- Position
- 31,201,486–31,203,450 (−)
- Aliases
- ASC, CARD5, TMS, TMS-1, TMS1
- Ensembl
- ENSG00000103490
- RefSeq RNA
- NM_013258.5, NM_145182.3, NM_145183.1
- RefSeq protein
- NP_037390.2, NP_660183.1
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
PYD and CARD domain containing
- Symbol
- PYCARD
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:31,201,486-31,203,450
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PYCARD PDB 1ucp.png
Show 5 more facts
- HomoloGene ID
- 8307
- exact match
- identifiers.org/ncbigene/29108
- genomic end
- 31214771
- genomic start
- 31201486
- cytogenetic location
- 16p11.2
Sources (4)
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- Further reading
PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene. It is localized mainly in the nucleus of monocytes and macrophages. In case of pathogen infection, however, it relocalizes rapidly to the cytoplasm, perinuclear space, endoplasmic reticulum and mitochondria and it is a key adaptor protein in activation of the inflammasome.
NMR structure of full-length ASC: PDB ID 2KN6