RNF8

Also known as hRNF8, ring finger protein 8

E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene. RNF8 has activity both in immune system functions and in DNA repair.

Gene data

RNF8

Name: ring finger protein 8
Type: protein-coding
Position: 37,353,979–37,394,734 (+)
Aliases: hRNF8
Ensembl: ENSG00000112130
RefSeq RNA: NM_003958.4, NM_183078.3, NR_046399.2
RefSeq protein: NP_003949.1, NP_898901.1

The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].

Pathways

Cell Cycle DNA Double-Strand Break Repair Homology Directed Repair Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)Nonhomologous End-Joining (NHEJ)DNA Double Strand Break Response Processing of DNA double-strand break ends G2/M DNA damage checkpoint G2/M Checkpoints

via MyGene.info

Gene · Ensembl

ring finger protein 8

Symbol: RNF8
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:37,353,970-37,394,737
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein RNF8 PDB 2csw.png

Show 5 more facts

HomoloGene ID: 2944
exact match: identifiers.org/ncbigene/9025
genomic end: 37394734
genomic start: 37353979
cytogenetic location: 6p21.2

Sources (4)

via Wikidata · CC0

~5 min read

Article

11 sections

Contents

Function
Chromatin remodeling
RNF8 in Homologous Recombinational Repair
RNF8 in Non-Homologous End Joining
RNF8 in Nucleotide Excision Repair
Impaired spermatogenesis
Interactions
See also
References
Further reading
External links

E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene. RNF8 has activity both in immune system functions and in DNA repair.

== Function ==