MDC1
Sign in to saveAlso known as NFBD1, mediator of DNA damage checkpoint 1
Mediator of DNA damage checkpoint protein 1 is a 2080 amino acid long protein that in humans is encoded by the MDC1 gene located on the short arm (p) of chromosome 6. MDC1 protein is a regulator of the Intra-S phase and the G2/M cell cycle checkpoints and recruits repair proteins to the site of DNA damage. It is involved in determining cell survival fate in association with tumor suppressor protein p53. This protein also goes by the name Nuclear Factor with BRCT Domain 1 (NFBD1).
Gene data
MDC1- Name
- mediator of DNA damage checkpoint 1
- Type
- protein-coding
- Aliases
- NFBD1
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
mediator of DNA damage checkpoint 1
- Symbol
- MDC1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_COX_CTG1:2,179,547-2,197,629
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein MDC1 PDB 2ado.png
Show 5 more facts
- HomoloGene ID
- 67092
- exact match
- identifiers.org/ncbigene/9656
- genomic start
- 30667584
- genomic end
- 30717447
- cytogenetic location
- 6p21.33
Sources (4)
via Wikidata · CC0
~9 min read
Article
11 sectionsContents
- Function
- Role in DNA damage response
- Role in apoptosis
- Role in meiosis
- Loss of MDC1 protein
- Interactions
- Protein structure
- Regulation
- Role in cancer
- References
- Further reading
Mediator of DNA damage checkpoint protein 1 is a 2080 amino acid long protein that in humans is encoded by the MDC1 gene located on the short arm (p) of chromosome 6. MDC1 protein is a regulator of the Intra-S phase and the G2/M cell cycle checkpoints and recruits repair proteins to the site of DNA damage. It is involved in determining cell survival fate in association with tumor suppressor protein p53. This protein also goes by the name Nuclear Factor with BRCT Domain 1 (NFBD1).
== Function ==