MRE11
Sign in to saveAlso known as ATLD, HNGS1, MRE11B, MRE11A, MRE11 homolog A, double strand break repair nuclease, MRE11 homolog, double strand break repair nuclease
Double-strand break repair protein MRE11 (Meiotic recombination 11) is an enzyme that in humans is encoded by the MRE11 gene. The gene has been designated MRE11A to distinguish it from the pseudogene MRE11B that is nowadays named MRE11P1.
Gene data
MRE11- Name
- MRE11 double strand break repair nuclease
- Type
- protein-coding
- Position
- 94,415,570–94,512,676 (−)
- Aliases
- ATLD, HNGS1, MRE11A, MRE11B
- Ensembl
- ENSG00000020922
- RefSeq RNA
- NM_001330347.2, NM_001440460.1, NM_001440461.1, NM_001440462.1, NM_001440463.1
- RefSeq protein
- NP_001317276.1, NP_001427389.1, NP_001427390.1, NP_001427391.1, NP_001427392.1
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
MRE11 double strand break repair nuclease
- Symbol
- MRE11
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:94,415,570-94,512,676
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~3 min read
Encyclopedic overview
7 sectionsContents
- Function
- Orthologs
- Overexpression in cancer
- Interactions
- See also
- References
- Further reading
Double-strand break repair protein MRE11 (Meiotic recombination 11) is an enzyme that in humans is encoded by the MRE11 gene. The gene has been designated MRE11A to distinguish it from the pseudogene MRE11B that is nowadays named MRE11P1.
== Function ==
Excerpted from Wikipedia’s “MRE11” article, available under the CC BY-SA 4.0 licence.