TERF2
Sign in to saveAlso known as TRBF2, TRF2, telomeric repeat binding factor 2
protein-coding gene in the species Homo sapiens
Gene data
TERF2- Name
- telomeric repeat binding factor 2
- Type
- protein-coding
- Position
- 69,355,464–69,408,571 (−)
- Aliases
- TRBF2, TRF2
- Ensembl
- ENSG00000132604
- RefSeq RNA
- NM_005652.5, XM_005256121.4, XM_005256122.4, XM_005256123.4, XM_005256124.5
- RefSeq protein
- NP_005643.2, XP_005256178.1, XP_005256179.1, XP_005256180.1, XP_005256181.1
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidineCleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purineRecognition and association of DNA glycosylase with site containing an affected purineCleavage of the damaged purineCleavage of the damaged purineMeiotic synapsisReproductionMeiosisTelomere Maintenance
via MyGene.info
Gene · Ensembl
telomeric repeat binding factor 2
- Symbol
- TERF2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:69,355,464-69,408,571
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Part of
- shelterin complex
- Image
- Protein TERF2 PDB 1h6p.png
Show 8 more facts
- HomoloGene ID
- 4133
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7014
- genomic start
- 69355567
- chromosome
- human chromosome 16
- genomic end
- 69442474
- cytogenetic location
- 16q22.1
- expressed in
- gastrocnemius muscle
Sources (3)
via Wikidata · CC0