rosuvastatin

Also known as ZD4522, (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid, (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[ethyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoic acid, AZD4522, S-4522

Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. It is recommended to be used with dietary changes, exercise, and weight loss. It is taken orally (by mouth).

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 464383832
Drug.image: Rosuvastatin structure.svg
Drug.image_class: skin-invert-image
Drug.width: 275
Drug.image2: Rosuvastatin-3D-balls.png
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Drug.USAN: Rosuvastatin calcium
Drug.tradename: Crestor, others
Drug.MedlinePlus: a603033
Drug.DailyMedID: Rosuvastatin
Drug.pregnancy_AU

~13 min read

Article

16 sections

Contents

Medical uses
Effects on cholesterol levels
Side effects and contraindications
Myopathy
Diabetes mellitus
Drug interactions
Structure
Mechanism of action
Pharmacodynamics
Pharmacokinetics
Society and culture
Economics
Legal status
Patent protection and generic versions
Debate and criticisms
References

Common side effects include abdominal pain, nausea, headaches, and muscle pains. Serious side effects may include rhabdomyolysis, liver problems, and diabetes. Use during pregnancy may harm the baby. Like all statins, rosuvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol.