Structure via PubChem · Public domain (PubChem)
rosuvastatin
Sign in to saveAlso known as ZD4522, (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid, (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[ethyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoic acid, AZD4522, S-4522
Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. It is recommended to be used with dietary changes, exercise, and weight loss. It is taken orally (by mouth).
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464383832
- Drug.image
- Rosuvastatin structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 275
- Drug.image2
- Rosuvastatin-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.USAN
- Rosuvastatin calcium
- Drug.tradename
- Crestor, others
- Drug.MedlinePlus
- a603033
- Drug.DailyMedID
- Rosuvastatin
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- Oral (by mouth)
- Drug.ATC_prefix
- C10
- Drug.ATC_suffix
- AA07
- Drug.ATC_supplemental
- , , , , , , , , , , , ,
- Drug.legal_AU
- S4
via Wikipedia infobox
Chemical data
- Formula
- C22H28FN3O6S
- Molecular weight
- 481.5 g/mol
- IUPAC name
- (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
- SMILES
- CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C
- InChIKey
- BPRHUIZQVSMCRT-VEUZHWNKSA-N
- XLogP
- 1.6
- Polar surface area
- 149 Ų
- H-bond donors
- 3
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 481.168285
Show 6 more facts
- defined daily dose
- 10
- chemical formula
- C₂₂H₂₈FN₃O₆S
- canonical SMILES
- CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C
- isomeric SMILES
- CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C
- World Health Organisation international non-proprietary name
- rosuvastatin
- Commons category
- Rosuvastatin
Sources (7)
via Wikidata · CC0
~13 min read
Article
16 sectionsContents
- Medical uses
- Effects on cholesterol levels
- Side effects and contraindications
- Myopathy
- Diabetes mellitus
- Drug interactions
- Structure
- Mechanism of action
- Pharmacodynamics
- Pharmacokinetics
- Society and culture
- Economics
- Legal status
- Patent protection and generic versions
- Debate and criticisms
- References
Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. It is recommended to be used with dietary changes, exercise, and weight loss. It is taken orally (by mouth).
Common side effects include abdominal pain, nausea, headaches, and muscle pains. Serious side effects may include rhabdomyolysis, liver problems, and diabetes. Use during pregnancy may harm the baby. Like all statins, rosuvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol.