dextrothyroxine
Also known as Choloxin®, D-T4, D-thyroxine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine, DT4, O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine
Dextrothyroxine (trade name Choloxin) is a dextrorotary isomer of thyroxine. It saw research as a cholesterol-lowering drug but was pulled due to cardiac side-effects. It increases hepatic lipase which in turn improves utilization of triglycerides and decreases levels of lipoprotein(a) in blood serum.
Chemical data
- Formula
- C15H11I4NO4
- Molecular weight
- 776.87 g/mol
- IUPAC name
- (2R)-2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate
via PubChem
Research
309 papers- THE EFFECTS OF DEXTROTHYROXINE IN DIABETES.California medicine · 1964
- Dextrothyroxine.New York state journal of medicine · 1972
- Comparative effectiveness of dextrothyroxine and levothyroxine in correcting hypothyroidism and lowering blood lipid levels in hypothyroid patients.The Journal of clinical endocrinology and metabolism · 1979
- Dextrothyroxine for lowering cholesterol.The Medical letter on drugs and therapeutics · 1976
- Adverse effects of hypolipidaemic drugs.
Article
1 sectionsContents
- References
Dextrothyroxine (trade name Choloxin) is a dextrorotary isomer of thyroxine. It saw research as a cholesterol-lowering drug but was pulled due to cardiac side-effects. It increases hepatic lipase which in turn improves utilization of triglycerides and decreases levels of lipoprotein(a) in blood serum.
== References ==