Structure via PubChem · Public domain (PubChem)
右旋甲状腺素
Sign in to saveAlso known as Choloxin®, D-T4, D-thyroxine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine, DT4, Dextrothyroxine, O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine
Dextrothyroxine (trade name Choloxin) is a dextrorotary isomer of thyroxine. It saw research as a cholesterol-lowering drug but was pulled due to cardiac side-effects. It increases hepatic lipase which in turn improves utilization of triglycerides and decreases levels of lipoprotein(a) in blood serum.
In the Vinony graph
Vinony's link graph records 145 inbound references to 右旋甲状腺素, and connects out to propranolol, hypolipidemic and liver.
It is catalogued under topics including Diphenyl ethers, Drugs with no legal status and ECHA InfoCard ID from Wikidata.
Vinony links it to 11 Wikipedia language editions.
Chemical data
- Formula
- C15H11I4NO4
- Molecular weight
- 776.87 g/mol
- IUPAC name
- (2R)-2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1967
- Admin. routes
- oral
- Indications
- cardiovascular disease, Down syndrome
via ChEMBL · EBI
Research
309 papers- THE EFFECTS OF DEXTROTHYROXINE IN DIABETES.California medicine · 1964
- Dextrothyroxine.New York state journal of medicine · 1972
- Comparative effectiveness of dextrothyroxine and levothyroxine in correcting hypothyroidism and lowering blood lipid levels in hypothyroid patients.The Journal of clinical endocrinology and metabolism · 1979
- Dextrothyroxine for lowering cholesterol.The Medical letter on drugs and therapeutics · 1976
- Adverse effects of hypolipidaemic drugs.Medical toxicology · 1987
via PubMed
Wikidata facts
- Subclass of
- thyroxine
- Mass
- 776.6867
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₅H₁₁I₄NO₄
- medical condition treated
- coronary artery disease
- canonical SMILES
- C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
- isomeric SMILES
- C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@H](C(=O)O)N
- defined daily dose
- 4
Sources (3)
via Wikidata · CC0
Available in 11 languages
via Wikidata sitelinks · CC0