S100A10
Sign in to saveAlso known as 42C, ANX2L, ANX2LG, CAL1L, CLP11, Ca[1], GP11, P11
S100 calcium-binding protein A10 (S100A10), also known as p11, is a protein that is encoded by the S100A10 gene in humans and the S100a10 gene in other species. S100A10 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells. They regulate a number of cellular processes such as cell cycle progression and differentiation. The S100 protein is implicated in exocytosis and endocytosis by reorganization of F-actin.
Gene data
S100A10- Name
- S100 calcium binding protein A10
- Type
- protein-coding
- Position
- 151,981,697–151,993,891 (−)
- Aliases
- 42C, ANX2L, ANX2LG, CAL1L, CLP11, Ca[1], GP11, P11, p10
- Ensembl
- ENSG00000197747
- RefSeq RNA
- NM_002966.3
- RefSeq protein
- NP_002957.1
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
S100 calcium binding protein A10
- Symbol
- S100A10
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:151,981,697-151,993,891
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~16 min read
Encyclopedic overview
16 sectionsContents
- Gene
- Structure
- Function
- Interactions
- Table 1
- Regulation
- Regulation of protein activity
- Regulation of transcription
- Table 2
- Clinical significance
- Depression
- Treatment
- Future clinical trials
- References
- Further reading
- External links
S100 calcium-binding protein A10 (S100A10), also known as p11, is a protein that is encoded by the S100A10 gene in humans and the S100a10 gene in other species. S100A10 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells. They regulate a number of cellular processes such as cell cycle progression and differentiation. The S100 protein is implicated in exocytosis and endocytosis by reorganization of F-actin.
The p11 protein is linked with the transport of neurotransmitters. Found in the brain of humans and other mammals, it has been implicated in the regulation of mood. In addition, due to its interaction with serotonin-signaling proteins and its correlation with symptoms of mood disorders, p11 is a new potential target for drug therapy.
Excerpted from Wikipedia’s “S100A10” article, available under the CC BY-SA 4.0 licence.