S100A10

Also known as 42C, ANX2L, ANX2LG, CAL1L, CLP11, Ca[1], GP11, P11

S100 calcium-binding protein A10 (S100A10), also known as p11, is a protein that is encoded by the S100A10 gene in humans and the S100a10 gene in other species. S100A10 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells. They regulate a number of cellular processes such as cell cycle progression and differentiation. The S100 protein is implicated in exocytosis and endocytosis by reorganization of F-actin.

Gene data

S100A10

Name: S100 calcium binding protein A10
Type: protein-coding
Aliases: 42C, ANX2L, ANX2LG, CAL1L, CLP11, Ca[1], GP11, P11, p10

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008].

via MyGene.info

~16 min read

Article

16 sections

Contents

Gene
Structure
Function
Interactions
Table 1
Regulation
Regulation of protein activity
Regulation of transcription
Table 2
Clinical significance
Depression
Treatment
Future clinical trials
References
Further reading
External links

The p11 protein is linked with the transport of neurotransmitters. Found in the brain of humans and other mammals, it has been implicated in the regulation of mood. In addition, due to its interaction with serotonin-signaling proteins and its correlation with symptoms of mood disorders, p11 is a new potential target for drug therapy.