S100A8
Sign in to saveAlso known as 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF
S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene. It is also known as calgranulin A.
Gene data
S100A8- Name
- S100 calcium binding protein A8
- Type
- protein-coding
- Aliases
- 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MRP8, NIF, P8
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
via MyGene.info
Gene · Ensembl
S100 calcium binding protein A8
- Symbol
- S100A8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:153,390,018-153,422,638
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein S100A8 PDB 1mr8.png
Show 5 more facts
- exact match
- identifiers.org/ncbigene/6279
- HomoloGene ID
- 2225
- genomic end
- 153391073
- genomic start
- 153362508
- cytogenetic location
- 1q21.3
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene. It is also known as calgranulin A.
The proteins S100A8 and S100A9 form a heterodimer called calprotectin.