SEC63
Sign in to saveAlso known as DNAJC23, ERdj2, PRO2507, SEC63L, SEC63 homolog, protein translocation regulator, PCLD2
Translocation protein SEC63 homolog is a protein that in humans is encoded by the SEC63 gene.
Gene data
SEC63- Name
- SEC63 protein translocation regulator
- Type
- protein-coding
- Position
- 107,867,756–107,958,309 (−)
- Aliases
- DNAJC23, ERdj2, PCLD2, PRO2507, SEC63L
- Ensembl
- ENSG00000025796
- RefSeq RNA
- NM_007214.5, NM_018529.1, XM_047418130.1, XM_047418131.1, XM_054354130.1
- RefSeq protein
- NP_009145.1, XP_047274086.1, XP_047274087.1, XP_054210105.1
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SEC63 protein translocation regulator
- Symbol
- SEC63
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:107,867,756-107,958,311
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 5220
- genomic start
- 107867756
- exact match
- identifiers.org/ncbigene/11231
- genomic end
- 107958208
- cytogenetic location
- 6q21
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Translocation protein SEC63 homolog is a protein that in humans is encoded by the SEC63 gene.
== Function ==