Gene data
SIRT3- Name
- sirtuin 3
- Type
- protein-coding
- Position
- 215,026–236,931 (−)
- Aliases
- SIR2L3
- Ensembl
- ENSG00000142082
- RefSeq RNA
- NM_001017524.3, NM_001370310.1, NM_001370312.1, NM_001370314.1, NM_001370315.1
- RefSeq protein
- NP_001017524.1, NP_001357239.1, NP_001357241.1, NP_001357243.1, NP_001357244.1
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019].
Gene Ontology
Biological process
Molecular function
Pathways
Nicotinate and nicotinamide metabolism - Homo sapiens (human)Central carbon metabolism in cancer - Homo sapiens (human)Aerobic respiration and respiratory electron transportMetabolismMitochondrial biogenesisOrganelle biogenesis and maintenanceGeneric Transcription PathwayGeneric Transcription PathwayTranscriptional activation of mitochondrial biogenesisCellular responses to stress
via MyGene.info
Gene · Ensembl
sirtuin 3
- Symbol
- SIRT3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:215,026-236,931
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI