SLC6A19

Also known as B0AT1, HND, solute carrier family 6 member 19

protein-coding gene in the species Homo sapiens

In the Vinony graph

Within Vinony's link graph, SLC6A19 is referenced by 298 other articles, and connects out to PubMed, transmembrane transport proteins and Ensembl genome database project.

Vinony files it under Genes on human chromosome 5 and Solute carrier family.

Its subject is documented across 5 Wikipedia language editions.

Gene data

SLC6A19

Name: solute carrier family 6 member 19
Type: protein-coding
Position: 1,201,595–1,225,111 (+)
Aliases: B0AT1, HND
Ensembl: ENSG00000174358
RefSeq RNA: NM_001003841.3, XM_054352501.1
RefSeq protein: NP_001003841.1, XP_054208476.1

This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene may result in Hartnup disorder, an inherited disease with symptoms such as pellagra, cerebellar ataxia, and psychosis. The expression and function of B0AT1 (SLC6A19) in intestinal cells depends on the presence of the accessory protein angiotensin-converting enzyme 2 (ACE2) which, among other functions, acts as a chaperone for membrane trafficking of B0AT1. The ACE2 is also the cellular receptor for severe acute respiratory syndrome-coronavirus (SARS-CoV) and for SARS-CoV-2 that is causing the coronavirus 2019 (COVID-19) pandemic [provided by RefSeq, Jul 2020].