(−)-sparteine
Sign in to saveSparteine is a class 1a antiarrhythmic agent and sodium channel blocker. It is an alkaloid and can be extracted from scotch broom. It is the predominant alkaloid in Lupinus mutabilis, and is thought to chelate the bivalent metals calcium and magnesium. It is not FDA approved for human use as an antiarrhythmic agent, and it is not included in the Vaughan Williams classification of antiarrhythmic drugs.
Research
1,343 papers- Sparteine.Archives internationales de pharmacodynamie et de therapie · 1948
- Sparteine as an anticonvulsant drug: Evidence and possible mechanism of action.Seizure · 2016
- The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms.Pharmacology & therapeutics · 1990
- [Pachycarpine].Fel'dsher i akusherka · 1954
- [CORDISANOL].Medizinische Klinik · 1953
via PubMed
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Encyclopedic overview
5 sectionsContents
- Biosynthesis
- Via 17-oxosparteine synthase
- See also
- References
- External links
Sparteine is a class 1a antiarrhythmic agent and sodium channel blocker. It is an alkaloid and can be extracted from scotch broom. It is the predominant alkaloid in Lupinus mutabilis, and is thought to chelate the bivalent metals calcium and magnesium. It is not FDA approved for human use as an antiarrhythmic agent, and it is not included in the Vaughan Williams classification of antiarrhythmic drugs.
It is also used as a chiral ligand in organic chemistry, especially in syntheses involving organolithium reagents.
Excerpted from Wikipedia’s “(−)-sparteine” article, available under the CC BY-SA 4.0 licence.