SPDEF

Also known as PDEF, bA375E1.3, SAM pointed domain containing ETS transcription factor

SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.

Gene data

SPDEF

Name: SAM pointed domain containing ETS transcription factor
Type: protein-coding
Position: 34,537,796–34,556,333 (−)
Aliases: PDEF, bA375E1.3
Ensembl: ENSG00000124664
RefSeq RNA: NM_001252294.2, NM_012391.3, XM_005248988.6, XM_011514457.4, XM_054355092.1
RefSeq protein: NP_001239223.1, NP_036523.1, XP_005249045.2, XP_011512759.1, XP_054211067.1

The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cell differentiation positive regulation of apoptotic process

Molecular function

DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity protein binding sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding sequence-specific double-stranded DNA binding

Cellular component

chromatin nucleus nucleus

via MyGene.info

Gene · Ensembl

SAM pointed domain containing ETS transcription factor

Symbol: SPDEF
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:34,537,796-34,556,358
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein SPDEF PDB 1yo5.png

Show 5 more facts

HomoloGene ID: 8231
exact match: identifiers.org/ncbigene/25803
genomic end: 34524110
genomic start: 34505579
cytogenetic location: 6p21.31

Sources (3)

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Further reading

SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.

PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM]