spiperone
Sign in to saveAlso known as R-5147, spiroperidol, spiropitan, 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one, 8-(3-p-fluorobenzoyl-1-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro(4,5)decane, 8-(3-(p-fluorobenzoyl)propyl)-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one
Spiperone, also known as spiroperidol and sold under the brand name Spiropitan ((JP)) is a typical antipsychotic of the butyrophenone family related to haloperidol. It is approved for clinical use in Japan as a treatment for schizophrenia.
Research
4,148 papers- Spiperone: Tritium labelling at high specific activity.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2019
- Spiperone Stimulates Regeneration in Pulmonary Endothelium Damaged by Cigarette Smoke and Lipopolysaccharide.International journal of chronic obstructive pulmonary disease · 2021
- Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists.Current topics in medicinal chemistry · 2002
- Anticancer Effects of Spiperone in C57BL/6 Mice with Emphysema and Lung Carcinoma.Bulletin of experimental biology and medicine · 2024
- Verification of the role of spiperone in the treatment of COPD through bioinformatics analysis.International immunopharmacology · 2021
via PubMed
Wikidata facts
- Mass
- 395.200905
Show 4 more facts
- chemical formula
- C₂₃H₂₆FN₃O₂
- canonical SMILES
- C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCC(=O)C4=CC=C(C=C4)F
- World Health Organisation international non-proprietary name
- spiperone
- Commons category
- Spiperone
via Wikidata · CC0
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Article
6 sectionsContents
- Pharmacology
- Pharmacodynamics
- Chemistry
- Derivatives
- See also
- References
Spiperone, also known as spiroperidol and sold under the brand name Spiropitan ((JP)) is a typical antipsychotic of the butyrophenone family related to haloperidol. It is approved for clinical use in Japan as a treatment for schizophrenia.
==Pharmacology== ===Pharmacodynamics=== {| class="wikitable floatleft" |+ Spiperone at targets |- ! Receptor !! Ki (nM) !! Notes |- | 5-HT1A || 17.3 || |- | 5-HT1B || 995 || |- | 5-HT1D || 2397 || |- | 5-HT1E || 5051 || |- | 5-HT1F || 3.98 || |- | 5-HT2A || 1.17 || |- | 5-HT2B || 0.8–1114.2 || 0.8 is bovine |- | 5-HT2C || 922.9 || |- | 5-HT3 || >10000 || Rat/other |- | 5-HT5A || 2512 || Mouse |- | 5-HT6 || 1590 || Rat |- | 5-HT7 || 109.8 || |- | α1A || 20.4 || |- | α1B || 3.09 || |- | α1D || 8.32 || |- | D1 || 398.5 || |- | D2 || 0.16 || |- | D3 || 0.34 || |- | D4 || 1.39 || |- | D5 || 4500 || |- | H1 || 272 || |- | σ || 353 || |}