spironolactone

Also known as Aldactone®, spiractin, spirotone, spironolattone, Spirnolactone, Aldactone, Spironolactonum, Spironolattone

thumb|Spironolactone 25 mg Spironolactone, sold under the brand name Aldactone among others, is classed as a diuretic medication. It can be used to treat fluid build-up due to liver disease or kidney disease. It is also used to reduce risk of disease progression, hospitalization, and death due to some types of heart failure. Other uses include acne and excessive hair growth in women, low blood potassium that does not improve with supplementation, high blood pressure that is difficult to treat, and early puberty in boys. It can also be used to block the effects of testosterone as a part of fem

Key facts

Drug.Watchedfields: changed
Drug.verifiedrevid: 470470172
Drug.image: Spironolacton.svg
Drug.image_class: skin-invert-image
Drug.alt: Skeletal formula of spironolactone
Drug.width: 235
Drug.image2: Spironolactone 3D ball.png
Drug.image_class2: bg-transparent
Drug.alt2: Ball-and-stick model of the spironolactone molecule
Drug.width2: 225
Drug.pronounce: ,
Drug.tradename: Aldactone, others
Drug.MedlinePlus: a682627
Drug.DailyMedID: Spironolactone
Drug.pregnancy_AU: B3
Drug.routes_of_administration: By mouth, topical
Drug.class: Antimineralocorticoid; Steroidal antiandrogen
Drug.ATC_prefix: C03

via Wikipedia infobox

Chemical data

Formula: C24H32O4S
Molecular weight: 416.6 g/mol
IUPAC name: S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate
SMILES: CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C
InChIKey: LXMSZDCAJNLERA-ZHYRCANASA-N
XLogP: 2.9
Polar surface area: 85.7 Å²
H-bond donors: 0
H-bond acceptors: 5
Formal charge: 0

via PubChem

Research

10,780 papers

Spironolactone.American heart journal · 1978
Spironolactone for Acne: Practical Strategies for Optimal Clinical Outcomes.Cutis · 2025
The spironolactone renaissance.Expert opinion on investigational drugs · 2001
Spironolactone.IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans · 1980
Spironolactone management of resistant hypertension.The Annals of pharmacotherapy · 2010

via PubMed

~49 min read

Encyclopedic overview

41 sections

Contents

Medical uses
Heart failure
High blood pressure
High aldosterone levels
Skin and hair conditions
Comparison
Transgender hormone therapy
Forms
Contraindications
Side effects
High potassium levels
Breast changes
Menstrual disturbances
Mood changes
Lipid changes
Rare reactions
Spironolactone bodies
Pregnancy and breastfeeding
Overdose
Interactions
Pharmacology
Pharmacodynamics
Pharmacokinetics
Absorption
Distribution
Metabolism
Elimination
Chemistry
Names
Analogues
Synthesis
History
Society and culture
Generic names
Brand names
Availability
Research
Prostate conditions
Epstein–Barr virus
Other conditions
References

thumb|Spironolactone 25 mg

Spironolactone, sold under the brand name Aldactone among others, is classed as a diuretic medication. It can be used to treat fluid build-up due to liver disease or kidney disease. It is also used to reduce risk of disease progression, hospitalization, and death due to some types of heart failure. Other uses include acne and excessive hair growth in women, low blood potassium that does not improve with supplementation, high blood pressure that is difficult to treat, and early puberty in boys. It can also be used to block the effects of testosterone as a part of feminizing hormone therapy. Spironolactone is usually available in tablets, taken by mouth, though topical forms are also available.

Excerpted from Wikipedia’s “spironolactone” article, available under the CC BY-SA 4.0 licence.