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GeneQ18050559· pop 8· linked from 755 articles

TAAR1

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Also known as TA1, TAR1, TRAR1, trace amine associated receptor 1, Trace amine receptor

Trace amine-associated receptor 1 (TAAR1) is a trace amine-associated receptor (TAAR) protein that in humans is encoded by the TAAR1 gene.

Gene data

TAAR1
Name
trace amine associated receptor 1
Type
protein-coding
Position
132,643,312–132,659,207 (−)
Aliases
TA1, TAR1, TRAR1
Ensembl
ENSG00000146399
RefSeq RNA
NM_138327.4
RefSeq protein
NP_612200.1

The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015].

Gene Ontology

Pathways

Neuroactive ligand-receptor interaction - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)Amine ligand-binding receptorsGPCR downstream signallingG alpha (s) signalling eventsGPCR ligand binding

via MyGene.info

Gene · Ensembl

trace amine associated receptor 1

Symbol
TAAR1
Biotype
Protein coding
Organism
Homo sapiens
Location
6:132,643,312-132,659,207
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
TAAR1 organ-specific expression and function.jpg
Show 9 more facts
HomoloGene ID
24938
Commons category
TAAR1
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/134864
genomic start
132643312
chromosome
human chromosome 6
genomic end
132659182
cytogenetic location
6q23.2
expressed in
body of stomach
Sources (3)

via Wikidata · CC0

~25 min read

Encyclopedic overview

20 sections
Contents
  • Discovery
  • Structure
  • Gene
  • Tissue distribution
  • Location within neurons
  • Receptor oligomers
  • Ligands
  • Agonists
  • Endogenous
  • Exogenous
  • Antagonists and inverse agonists
  • Function
  • Monoaminergic systems
  • Immune system
  • Clinical significance
  • Research
  • See also
  • Notes
  • References
  • External links

Trace amine-associated receptor 1 (TAAR1) is a trace amine-associated receptor (TAAR) protein that in humans is encoded by the TAAR1 gene.

TAAR1 is a primarily intracellular amine-activated and G protein-coupled receptor (GPCR) that is primarily expressed in several peripheral organs and cells (e.g., the stomach, small intestine, duodenum, and white blood cells), astrocytes, and in the intracellular milieu within the presynaptic plasma membrane (i.e., axon terminal) of monoamine neurons in the central nervous system (CNS).

Excerpted from Wikipedia’s “TAAR1” article, available under the CC BY-SA 4.0 licence.

Available in 7 languages

via Wikidata sitelinks · CC0