TAAR1

Also known as TA1, TAR1, TRAR1, trace amine associated receptor 1, Trace amine receptor

Trace amine-associated receptor 1 (TAAR1) is a trace amine-associated receptor (TAAR) protein that in humans is encoded by the TAAR1 gene.

Gene data

TAAR1

Name: trace amine associated receptor 1
Type: protein-coding
Aliases: TA1, TAR1, TRAR1

The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015].

via MyGene.info

Gene · Ensembl

trace amine associated receptor 1

Symbol: TAAR1
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:132,643,312-132,659,207
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: TAAR1 organ-specific expression and function.jpg

Show 6 more facts

HomoloGene ID: 24938
Commons category: TAAR1
exact match: identifiers.org/ncbigene/134864
genomic start: 132643312
genomic end: 132659182
cytogenetic location: 6q23.2

Sources (3)

via Wikidata · CC0

~25 min read

Article

20 sections

Contents

Discovery
Structure
Gene
Tissue distribution
Location within neurons
Receptor oligomers
Ligands
Agonists
Endogenous
Exogenous
Antagonists and inverse agonists
Function
Monoaminergic systems
Immune system
Clinical significance
Research
See also
Notes
References
External links

Trace amine-associated receptor 1 (TAAR1) is a trace amine-associated receptor (TAAR) protein that in humans is encoded by the TAAR1 gene.

TAAR1 is a primarily intracellular amine-activated and G protein-coupled receptor (GPCR) that is primarily expressed in several peripheral organs and cells (e.g., the stomach, small intestine, duodenum, and white blood cells), astrocytes, and in the intracellular milieu within the presynaptic plasma membrane (i.e., axon terminal) of monoamine neurons in the central nervous system (CNS).