TAGLN

Also known as SM22, SMCC, TAGLN1, WS3-10, transgelin, SM22-alpha

Transgelin is a protein that in humans is encoded by the TAGLN gene.

Gene data

TAGLN

Name: transgelin
Type: protein-coding
Aliases: SM22, SM22-alpha, SMCC, TAGLN1, TGLN, WS3-10

This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017].

via MyGene.info

Gene · Ensembl

transgelin

Symbol: TAGLN
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:117,197,509-117,207,464
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein TAGLN PDB 1ujo.png

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HomoloGene ID: 2398
exact match: identifiers.org/ncbigene/6876
genomic end: 117207464
genomic start: 117199370
cytogenetic location: 11q23.3

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Transgelin is a protein that in humans is encoded by the TAGLN gene.

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.